Paul A Northcott Selected Research

Medulloblastoma

5/2022	Author Correction: scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy.
1/2022	Vorinostat and isotretinoin with chemotherapy in young children with embryonal brain tumors: A report from the Pediatric Brain Tumor Consortium (PBTC-026).
1/2022	Combination of Ribociclib and Gemcitabine for the Treatment of Medulloblastoma.
1/2022	Revised clinical and molecular risk strata define the incidence and pattern of failure in medulloblastoma following risk-adapted radiotherapy and dose-intensive chemotherapy: results from a phase III multi-institutional study.
1/2022	The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors.
11/2021	Serial assessment of measurable residual disease in medulloblastoma liquid biopsies.
11/2021	Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth.
11/2021	Subgroup and subtype-specific outcomes in adult medulloblastoma.
9/2021	Efficacy of Carboplatin and Isotretinoin in Children With High-risk Medulloblastoma: A Randomized Clinical Trial From the Children's Oncology Group.
1/2021	Outcomes by Clinical and Molecular Features in Children With Medulloblastoma Treated With Risk-Adapted Therapy: Results of an International Phase III Trial (SJMB03).

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Paul A Northcott Research Topics

Disease

72	Medulloblastoma 05/2022 - 04/2009
59	Neoplasms (Cancer) 01/2022 - 12/2008
16	Brain Neoplasms (Brain Tumor) 01/2022 - 12/2008
9	Carcinogenesis 01/2020 - 04/2009
5	Neoplasm Metastasis (Metastasis) 01/2016 - 04/2012
3	Glioma (Gliomas) 01/2021 - 11/2013
3	Typical Teratoid Rhabdoid Tumor 01/2020 - 12/2012
2	Rhabdoid Tumor (Rhabdoid Tumors) 01/2022 - 01/2020
2	Pinealoma (Pineoblastoma) 01/2020 - 01/2020
1	Central Nervous System Diseases (CNS Diseases) 01/2022
1	Neurofibrosarcoma (MPNST) 01/2021
1	Genetic Predisposition to Disease (Genetic Predisposition) 01/2020
1	Ependymoma 01/2018
1	Renal Cell Carcinoma (Grawitz Tumor) 05/2017
1	CHARGE Syndrome 01/2017
1	Cerebellar Neoplasms 05/2016
1	Primitive Neuroectodermal Tumors (PNET) 02/2016
1	Astrocytoma (Pilocytic Astrocytoma) 08/2013

Drug/Important Bio-Agent (IBA)

14	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2009
10	MicroRNAs (MicroRNA)IBA 01/2021 - 01/2009
10	RNA (Ribonucleic Acid)IBA 01/2020 - 01/2010
9	Biological ProductsIBA 01/2021 - 07/2011
8	Formaldehyde (Formol)FDA Link 01/2016 - 04/2011
7	Biomarkers (Surrogate Marker)IBA 01/2022 - 10/2011
7	DNA (Deoxyribonucleic Acid)IBA 11/2013 - 01/2010
6	ChromatinIBA 01/2019 - 03/2013
6	ParaffinIBA 01/2016 - 04/2012
5	Histones (Histone)IBA 01/2018 - 04/2009
4	Pharmaceutical PreparationsIBA 01/2021 - 12/2014
3	Cell-Free Nucleic AcidsIBA 01/2022 - 11/2021
3	ProteomeIBA 01/2020 - 06/2015
3	hydrogen sulfite (bisulfite)IBA 05/2019 - 01/2010
3	Lysine (L-Lysine)FDA Link 01/2019 - 04/2009
3	Messenger RNA (mRNA)IBA 05/2016 - 10/2010
2	Small Cytoplasmic RNAIBA 05/2022 - 12/2019
2	Isotretinoin (Accutane)FDA LinkGeneric 01/2022 - 09/2021
2	Transcription Factors (Transcription Factor)IBA 01/2019 - 12/2018
2	EnzymesIBA 01/2019 - 01/2018
2	Small Interfering RNA (siRNA)IBA 01/2018 - 10/2010
2	IsotopesIBA 01/2018 - 06/2015
2	Carrier Proteins (Binding Protein)IBA 01/2017 - 10/2014
2	RNA Helicases (RNA Helicase)IBA 05/2016 - 08/2012
2	Telomerase (Telomerase Reverse Transcriptase)IBA 12/2013 - 12/2013
1	ribociclibIBA 01/2022
1	Circulating Tumor DNAIBA 01/2022
1	Vorinostat FDA Link 01/2022
1	Gemcitabine FDA Link 01/2022
1	Dyneins (Dynein)IBA 01/2022
1	Long Noncoding RNAIBA 01/2022
1	NucleotidesIBA 11/2021
1	KinesinsIBA 11/2021
1	Carboplatin (JM8)FDA LinkGeneric 09/2021
1	Long-Acting Thyroid Stimulator (LATS)IBA 01/2021
1	Methotrexate (Mexate)FDA LinkGeneric 12/2020
1	Co-Repressor ProteinsIBA 01/2020
1	SMARCB1 ProteinIBA 01/2020
1	CytokinesIBA 01/2020
1	Sucrose (Saccharose)IBA 01/2020
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2020
1	HhAntag691IBA 12/2019
1	Complement System Proteins (Complement)IBA 11/2018
1	histone H3 trimethyl Lys4IBA 01/2018
1	MethyltransferasesIBA 01/2018
1	Amino Acids FDA Link 01/2018
1	Eukaryotic Initiation Factor-4F (EIF4F)IBA 01/2018
1	Genetic Markers (Genetic Marker)IBA 05/2017
1	DNA HelicasesIBA 01/2017
1	Polycomb Repressive Complex 2IBA 01/2017
1	5' Untranslated Regions (5' UTR)IBA 05/2016
1	arseniteIBA 05/2016
1	Pyruvate KinaseIBA 06/2015
1	RibonucleoproteinsIBA 06/2015
1	Glycoproteins (Glycoprotein)IBA 05/2015
1	Tumor Biomarkers (Tumor Markers)IBA 05/2015
1	GSK 1363089IBA 01/2015
1	Phosphotransferases (Kinase)IBA 01/2015
1	LithiumIBA 12/2014
1	Radiation-Sensitizing AgentsIBA 12/2014
1	Plicamycin FDA Link 07/2014
1	Antineoplastic Agents (Antineoplastics)IBA 07/2014
1	Aurora KinasesIBA 10/2013
1	Polo-like KinasesIBA 10/2013
1	CytidineIBA 08/2013
1	Mitogen-Activated Protein KinasesIBA 08/2013
1	Transforming Growth Factor beta (TGF-beta)IBA 03/2013
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 11/2012
1	Indicators and Reagents (Reagents)IBA 11/2012
1	3-deazaneplanocinIBA 10/2012
1	NestinIBA 10/2012
1	Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)IBA 08/2012
1	Ion Channels (Ion Channel)IBA 08/2012

Therapy/Procedure

38	Therapeutics 05/2022 - 01/2009
10	Drug Therapy (Chemotherapy) 01/2022 - 01/2009
3	Craniospinal Irradiation 12/2020 - 01/2016
2	Radiotherapy 01/2022 - 01/2021
2	Transplantation 05/2012 - 02/2012
1	Precision Medicine 07/2017
1	Image-Guided Radiotherapy 01/2016
1	Chemoradiotherapy 01/2016
1	Caloric Restriction 05/2013